Niagen: An Anti-Aging & Fat Burning Super Supplement

Sean Torbati
Written By: Sean Torbati
November 4th, 2014
Updated: June 13th, 2020
Categories: Articles Supplements
30.9K Reads
Niagen allows you to improve cell function and energy performance by bolstering mitochondrial capacity. The result...Niagen functions as a potent anti-aging & fat burning super supplement.

Here is a bold statement that will get your attention...

HPN N(r) is the single biggest supplement innovation in the past 5 years.

If you have any interest in brain health, muscle endurance, metabolism or anti-aging, you will want to read the next few paragraphs.

In an industry ripe with BS, N(r) from High Performance Nutrition is an absolute blue chip; a product built on science and university clinical data.

N(R) by High Performance NutritionThe first thing you should know about N(r) is that it contains only one ingredient. That ingredient is Niagen. Niagen, scientifically known as nicotinamide riboside, is structurally a member of the B-Vitamin family.

Some of you better versed in science will immediately wonder what makes Niagen different from niacin or plain nicotinamide. The best way to explain this is to ask what makes gold different from your credit card or a bank check when traveling in a third world country with no electricity. Gold will be very easy to use and provides you with a lot of bargaining power. On the other hand your credit card and bank check will be virtually useless.

Our body’s inability to efficiently handle niacin in high dosages is well documented, and expressed by a sensation many of you have experienced...the "Niacin Flush". As far as nicotinamide, we cannot achieve the intended benefits without the nicotinamide riboside being absorbed and used in a cohesive manner. In fact, the differences between Niagen and niacin or nicotinamide are so unique that Niagen has three patents. These patents were granted for its production, usage to treat injured or diseased neurons, and its ability to increase the NAD+ coenzyme.

How N(r) Works in One Sentence

N(r) increases the level of NAD+ in every cell of our bodies.

Niagen has a host of benefits that include brain health, muscle endurance, metabolism and anti-aging. All of these benefits are tied into one simple fact: Niagen increases the level of NAD+ in our cells. Through the increase of this coenzyme, all of Niagen's benefits are made possible.

The neuroprotection enhancement capacity of N(r) makes it a no-brainer for athletes participating in contact sports. But many of you are thinking, "Great, that's awesome; but I don't play any sports, what can this really do for me?" The answer to that question is so profound that the rest of this article is dedicated to explaining why N(r) is perhaps the most important supplement you can possibly take, now and forever.

The Mitochondria - Factory Analogy

This needs to be understood, as it will provide a reference point for much of what is to come.

If you paid attention in middle school biology, you remember that the mitochondria are the "energy factories" of the cell. These factories are responsible for turning glucose, amino acids and fatty acids into ATP, our body’s usable energy source.

What wasn't covered in biology class was the fact that the capacity of mitochondria is mostly determined by their size and cristae content. Cristae are the channels of the mitochondria where most activity occurs. So essentially, they are the "assembly lines" of the mitochondrial "factory."

Bigger mitochondria with more cristae are like larger factories with more assembly lines.

High Performance Nutrition N(R)

Why is This Such a Big Deal?

Imagine you had a factory that made shoes. This factory would take in laces, soles and leather, and in turn would produce shoes.

Now assume that the factory could produce a maximum of 100 pair of shoes per day based on its size and the number of assembly lines in the factory. What would happen if you demanded that it produce 200 pair of shoes per day? Because 200 pair of shoes is far beyond the capacity of the factory, demanding such an output would put a great deal of stress on the factory. In turn, you would likely see a huge increase in the number of defects and waste.

Now using this logic, let's apply it to the mitochondria. Many researchers speculate that our mitochondria have become dysfunctional over the last couple thousand years of civilization, and that they are currently unable to meet the energy production needs we place upon them.

So, as with the shoe factory scenario, this situation creates an immense amount of mitochondrial stress. This increases the amount of free radical waste that the mitochondria puts out when trying to produce the ATP we need to fuel our bodies. As you can imagine, this will be particularly bad in both very active persons who demand a lot of ATP to fuel their activities; and in populations that have poor dietary habits including highly processed foods that may be harder for the body to metabolize.

The Free Radical Problem

So we are faced with a situation where the mitochondria are putting out a lot of free radicals into the cells. The problem with free radicals is that they speed up aging, and are thought to be a potential cause of cancer and other diseases.

The approach in the dietary supplement industry has been to take antioxidants in an attempt to neutralize these free radicals and prevent them from doing the harm they are known to do. The issue with this approach is that we are forever behind and unable to effectively manage the free radicals.

The analogy is similar to oil tankers spilling oil into the ocean. The oil in the ocean is like free radical in our bodies. When oil is spilled in the ocean, the immediate goal is to remove it. The machines and procedures that are used in an attempt to clean up the spill can be compared to antioxidants cleaning up free radicals in our bodies. The machines and the antioxidants can be effective; but certainly the vastly superior solution would be to minimize/prevent the oil spill or free radical production.

With oil companies the solution is simple, DON'T SPILL THE OIL. Our bodies however, have been a much greater challenge. How can we make our mitochondrial factories stronger, more functional, and more efficient to reduce the stress on them and thus minimize free radical output?

High Performance Nutrition N(R)

Now Lets Revisit WHAT N(r) DOES

N(r) has been proven in university research to:

  • INCREASE NAD+ levels to improve mitochondria-nucleus communication
  • INCREASE mitochondrial size
  • INCREASE mitochondrial cristae content
  • INCREASE the number of mitochondria (Mitochondrial Biogenesis)

If you recall, mitochondrial size and cristae content are two dominant factors in determining mitochondrial capacity. The third proven mitochondrial benefit of N(r) was that it actually increased the actual number of mitochondria in the cells.

So as a final recap, in this one supplement we have created a safe and effective means of giving you more mitochondria, each of which are functioning at a higher level than ever before possible.

However, it still gets better. Increasing mitochondrial function does more than just decrease free radical output. Additional benefits include:

  • Increased calorie expenditure (metabolism) - This can help create additional fat loss in conjunction with diet and exercise.
  • Increased ATP availability/production - ATP is a key component to maximizing energy levels and muscle performance in any activity or sport.

This makes N(r) a must have for anyone who takes their health, performance, or physique seriously.


Canto; The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity; Cell Metabolism (2012) 15:838-847.

Sasaki;Stimulationofnicotinamideadeninedinucleotidebiosyntheticpathwaysdelays axonal degeneration after axotomy; The Journal of Neuroscience (2006) 33:8484-8491.

Gomes: Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging; Cell Journal (2013)

Posted on: Mon, 12/01/2014 - 19:21

Sean, I've read the research as well as several reviews posted by other men claiming to have been taking this new supplement for a month or more. A couple have posted that they didn't really notice much benefit until they increased the dose to 250mg twice daily. Your thoughts on this? Are you taking this yourself?

Posted on: Sat, 03/28/2015 - 12:23

the bottle says one capsule is 250 mg. I know for a fact this works as far as aging I have seen it first hand with a family member. His skin looks great and he looks so much younger after just one month. I do not have a lot of money but I for one have seen it works and I bought a six month supply and am on my first bottle. Good luck and if u have the money try it.

Posted on: Mon, 11/17/2014 - 17:32

When an article begins "Why is This Such a Big Deal?" and goes off on "Imagine you had a factory that made shoes..." instead of "a university study with 2,000 subjects," then you are probably reading an advertisement not an article.

Posted on: Sun, 11/23/2014 - 23:02

Hi Todd, I was making an analogy everyone can follow and understand. The research is there for anyone to review if they want a strictly academic perspective.

Posted on: Mon, 11/17/2014 - 13:40

What is the suggested dosage? I have read 250 mg once a day to 500 mg twice a day.

Posted on: Sun, 11/23/2014 - 22:57

The dosage is 250mg it can be spread into two servings or taken all at once!

Posted on: Mon, 11/10/2014 - 15:38

Hi Sean,

So all the research done on this product shows that mice have taken this supplement at a dosage of 250-400 mg/kg a day. This would mean that a 200 pound male would have to take an entire bottle of the product in one day to equal what was given in the studies. Is there any data out there that this product will be effective in humans at this low dosage?

Posted on: Mon, 11/17/2014 - 11:38

Nope, probably because this is just another scam supplement that makes it sound scientifically amazing. If it worked, it would be all over the news, people wouldn't be fat, people wouldn't age and the pharmaceutical companies would own it. No way you could get this "magic" pill over the counter. Don't get me wrong, it may slightly work...but probably not good enough to pay $30 per month. If you wanna spend money to look younger and slimmer, go on a diet and get plastic'll actually get results from that!!

Posted on: Sun, 11/23/2014 - 23:04

Hi James, it does more than slightly work. Please read and understand the research. As far as being in the news, this has been featured on ABC, CBS, WSJ, and many other media outlets. No one is claiming a "magic pill" but it is absolutely a HUGE breakthrough in natural supplementation.

Posted on: Sun, 11/23/2014 - 23:00

Hi David, I won't hold it against you that you don't know this, but there is a surface area adjustment that needs to be taken into account when translating from animal to human data. Once you have done this, you will find that 250mg is a great dosage, with 500mg being on the high side. There is some great PK data forthcoming from a human trial that will also demonstrate and confirm our products effectiveness at this dosage. Be on the lookout for that before the end of the year! Thanks for your question.