The Science Behind Betancourt Nutrition’s PUMP’D

Elliot Reimers provides the inside scoop on the science behind Betancourt Nutrition's hot new pre-workout Pump'D, which provides massive pumps through nitric oxide support.

Pre-workout supplements are a dime a dozen these days so Betancourt Nutrition is proud to be releasing a product that sets itself apart from the competition with research-backed ingredients in nominal doses. PUMP’D will be the third pre-workout supplement in the Betancourt Nutrition lineup and will help athletes and trainees achieve a greater pump, intensify their focus, and push harder in the gym.

Many companies choose to egregiously load up their pre-workout products with bunk ingredients in inefficacious doses, but every ingredient in Pump’d was chosen with precision and meticulous attention to detail. Unlike many of those other run-of-the-mill pre-workout products, PUMP’D doesn’t rely on harsh stimulants that can desensitize the body to their effects after continual use; instead Betancourt Nutrition created the PUMP’D Performance Blend and Focus & Volume Blend which synergistically form a superb, blood-flow enhancing supplement.

Betancourt Nutrition is continually researching for the optimal ingredients to provide consumers with the highest quality, most efficacious products on the market, and PUMP’D is no exception. Let’s take a look at the science and research behind the PUMP’D formula and why it belongs in your supplement arsenal, especially if you are after skin-bursting pumps and next-level focus in the gym.

The PUMP’D Performance Blend

Hydromax: High Concentration Glycerol (1,000mg per serving)

Glycerol is a fat molecule with unique properties in humans. When ingested it is absorbed and increases the concentration of fluids in the blood and tissues. The body retains a balance in the concentration of these fluids, so when water is consumed with glycerol it is not excreted until the extra glycerol is removed via the kidneys or broken down by the body.

For users this means glycerol monostearate rapidly improves hydration and enhances the absorption of other ingredients taken with it. Ultimately this results in faster delivery of nutrients and enhanced "pump" effect during training, which is precisely why it has been implemented in the PUMP’D Performance Blend. PUMP’D contains the purest form of glycerol on the market—HydroMax, a patented high-potency glycerol. Other products often rely on cheaper a cheaper form of glycerol—glycerol monostearate (this inferior compound delivers a paltry 4 to 10% glycerol).

AgmaPure: Premium Grade Agmatine Sulfate (750mg per serving)

Agmatine is becoming an increasingly popular supplement due to its profound vasodilating effects. It was once thought that agmatine was not synthesized in higher life forms, but it is now known that humans do in fact produce agmatine in the brain. [1] There are multiple mechanisms that agmatine acts on to confer benefits, such as altering certain enzymes of the nitric oxide synthase (NOS) family, and by activating transmembrane receptors like imidazoline-1 and alpha(2)-adrenergic receptors. [2]

These reactions lead to enhanced vasodilation/blood flow, increased insulin sensitivity, and intensified focus, all of which are favorable to an athlete/trainee. PUMP’D utilizes arcane-free AgmaPure, a premium-grade form of agmatine sulfate.

Betancourt Pump'D

Betancourt Nutrition is continually researching for the optimal ingredients to provide consumers with the highest quality, most efficacious products on the market, and PUMP’D is no exception.

Pomegranate Extract (250mg per serving)

Pomegranate fruit is rife with antioxidants, and the ivory-colored seeds found within are full of ellagic acid--a compound with potent cardiovascular and liver health benefits. Studies have shown that pomegranate consumption greatly reduces oxidative stress and inhibits angiogenesis/lowers blood pressure. [4] As a result, pomegranate can help unclog your arteries and improve fat burning and blood flow. In this regard, PUMP’D is not merely just a pump product, but also improves overall health.

Beet Root (250mg per serving)

Beets are a rich source of natural chemicals called nitrates. When nitrates from beets are ingested the body utilizes them to synthesize nitric oxide which in turn enhances blood flow and lowers blood pressure. [5] Ultimately dietary nitrate decreases the amount of oxygen needed by muscles to contract, which has obvious benefits for athletes and trainees alike. The inclusion of Beet Root in PUMP’D will help propel you in the gym by providing a hefty dose of those dietary nitrates.

L-Norvaline (50mg per serving)

L-norvaline is a synthetically-made isomer of the branched-chain amino acid valine. It has been shown through research to have significant vasodilating effects by inhibiting the arginase enzyme and thus increasing concentrations of arginine (which is converted into nitric oxide). [6] PUMP’D includes L-norvaline to provide users with unparalleled blood flow and intensified muscle pumps.

The PUMP’D Focus & Volume Blend (1,650mg per serving)


L-tyrosine is an amino acid that plays an important role in the synthesis of catecholamines (dopamine, epinephrine and norepinephrine) which have cognitive benefits and have anxiolytic effects. [7]  The L-tyrosine in PUMP’D will thus help attenuate neurological fatigue that can arise from intense exercise.

Choline Bitartrate

Choline is a natural biomolecule in the Vitamin B complex that plays a variety of roles in maintaining optimum health. Choline deficiency is often indicated in states of increased anxiety, memory loss (and onset of Alzheimer’s Disease) and declined focus. [8] Therefore, PUMP’D includes choline bitartrate as a highly bioavailable form of choline, which is ultimately necessary for production of the neurotransmitter acetylcholine.


L-glutamine is the most abundant free-form amino acid in the blood stream of humans and is rather ubiquitous in terms of physiological effects. Research is continually growing for glutamine usage, and recent findings suggest that it acts a neuroprotectant against oxidative stress. [9] Moreover, prolonged exercise can alter hydration status and it is suggested that glutamine can improve fluid regulation. [10]


L-ornithine is a nonessential amino acid that plays a variety of roles in the body. For one, it is metabolized into L-arginine which can subsequently propel nitric oxide production. L-ornithine may also increase growth hormone and insulin levels and this can benefit those looking to grow muscle and lose fat. [11]

Endoginine: Premium Grade N-Carbamylglutamate

N-carbamylglutamate is an analogue of the biomolecule N-acetylglutamate and appears to be a highly efficacious compound for raising concentrations of arginine in the blood. [11] The increase in plasma arginine serves to increase levels of nitric oxide and increase muscle tissue production. PUMP’D utilizes Endoginine, a highly-purified form of N-carbamylglutamate, to provide users with exceptional blood flow.

Are you PUMP’D?!

Betancourt Nutrition is constantly striving to bring athletes and trainees superior products by leading the way of innovation in sports supplementation. PUMP’D is a precision blend of workout-enhancing ingredients that will take your performance in the gym to the next level.

The beauty of PUMP’D is that it may be stacked with our other pre-workout products (BullRush and D-Stunner) and it has a delicious, refreshing taste for you to look forward to drinking. Never have a bad workout again, get PUMP’D!


1. Halaris A, Plietz J. Agmatine : metabolic pathway and spectrum of activity in brain. CNS Drugs. 2007;21(11):885-900. Review. PubMed PMID: 17927294.

2. Chang CH, Wu HT, Cheng KC, Lin HJ, Cheng JT. Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats. Neurosci Lett. 2010 Jan 14;468(3):297-9. doi: 10.1016/j.neulet.2009.11.018. Epub 2009 Nov 12. PubMed PMID: 19913596.

3.  Su CH, Liu IM, Chung HH, Cheng JT. Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats.Neurosci Lett. 2009 Jul 3;457(3):125-8. doi: 10.1016/j.neulet.2009.03.093. Epub 2009 Apr 1. PubMed PMID: 19429177.

4.Aviram M, Dornfeld L, Rosenblat M, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation:studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 2000;71(5):1062-76. Aviram M, Dornfeld L. Pomeganate juice consumption inhibits serum angiotensin coverting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158(1):195-8.

5. Lundberg, Jon O., et al. "The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals." Nitrite and Nitrate in Human Health and Disease. Humana Press, 2011. 21-48.

6. Förstermann, Ulrich, and William C. Sessa. "Nitric oxide synthases: regulation and function." European heart journal 33.7 (2012): 829-837.

7. Fernstrom JD, Fernstrom MH. “Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain.” J Nutr. (2007)

8. Mineur, Yann S., et al. "Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety-and depression-like behavior." Proceedings of the National Academy of Sciences 110.9 (2013): 3573-3578.

9. Chen, Jianmin, and Karl Herrup. "Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress." PloS one 7.3 (2012): e33177.

10. Hoffman, Jay R., et al. "Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise." Journal of the International Society of Sports Nutrition 7.8 (2010).

11. Bucci, Luke, et al. "Ornithine ingestion and growth hormone release in bodybuilders." Nutrition Research 10.3 (1990): 239-245.